Testing performance of Cas9 activators

library-preparation method that is not contaminated with chimeric reads with an algorithm called Structural Variant Search (SVS) that identifies SVs on the basis of split read alignment and elimination of germline variants. Using a cell line with known viral integration sites, which serve as a surrogate for SVs, they determined that SVS has a specificity of 95% at a sensitivity of 36%. The authors also show that the number of SVs increases after treatment of healthy primary cells with two clastogenic compounds. Brief Communication p584